Effect of bushen yizhi recipe on neurotransmitter release in A beta segment neurotoxin induced NG108-15 cellular model of Alzheimer disease / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 50-53, 2002.
Article
em Zh
| WPRIM
| ID: wpr-304250
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Bushen Yizhi Recipe (BSYZR) on neurotransmitter release in A beta segment neurotoxin induced NG108-15 cellular model of Alzheimer disease (AD).</p><p><b>METHODS</b>The levels of choline acetyltransferase (ChAT) activity, synapsin and functional synapse formation rate in the cellular model treated with BSYZR containing serum were determined by Western blot analysis, immunoradiometric assay and electrophysiologic technique.</p><p><b>RESULTS</b>BSYZR containing serum treatment could cause increase of ChAT activity and synapsin level in model cells, as compared with those in normal control model cells treated with non-drug containing serum, it also could regulate the release capacity of transmitter and raise the functional synapse formation.</p><p><b>CONCLUSION</b>BSYZR could reduce the reaction of cell to A beta neurotoxin, indicating that it could be antagonistic to the pathological development of AD by means of raising the neurotransmitter release capacity.</p>
Texto completo:
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Índice:
WPRIM
Assunto principal:
Patologia
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Farmacologia
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Medicamentos de Ervas Chinesas
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Distribuição Aleatória
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Linhagem Celular
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Colina O-Acetiltransferase
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Peptídeos beta-Amiloides
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Sinapsinas
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Ratos Wistar
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Neurotransmissores
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2002
Tipo de documento:
Article