Effect of Panax notoginseng saponins on human kidney fibroblast / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 47-49, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-304251
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Panax notoginseng saponins (PNS) on cell proliferation, type I collagen secretion and integrin beta 1 expression in human kidney fibroblast (KFB).</p><p><b>METHODS</b>KFB were cultured and stimulated by PNS in vitro. The cell proliferation, type I collagen secretion and integrin beta 1 expression in KFB were measured by methyl thiazolyl tetrazolium (MTT), enzyme-linked immunoabsorbent assay (ELISA) and flowcytometry respectively.</p><p><b>RESULTS</b>Within its optimal concentration range and effective time range, PNS could obviously inhibit the proliferation, type I collagen secretion and integrin beta 1 expression (all P < 0.05) in human KFB.</p><p><b>CONCLUSION</b>PNS would possibly be an effective drug for renal interstitial fibrosis prevention and treatment.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Saponinas
/
Fibrose
/
Células Cultivadas
/
Química
/
Integrina beta1
/
Biologia Celular
/
Colágeno Tipo I
/
Fibroblastos
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2002
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS