Clinical and pathologic characteristics of Erdheim-Chester disease / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 809-813, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-304384
ABSTRACT
<p><b>OBJECTIVE</b>To explore the clinicopathologic features, immunophenotype, differential diagnosis and gene mutation status of the Erdheim-Chester disease (ECD).</p><p><b>METHODS</b>Clinical and pathologic findings of 3 ECD cases were examined by gross, microscopic, immunohistochemical methods and BRAF V600E mutation. Related literatures were reviewed.</p><p><b>RESULTS</b>Two male patients and one female patient presented clinically with multiple skin nodules, bone pain and bony lesions by imaging study. Microscopically, the lesions were composed of spindle-shaped fibroblasts, foamy histiocytes and scattered Touton-type giant cells embedded in reactive fibrous tissue. Lymphocytes, plasma cells, and multinucleated giant cells were also found. Immunohistochemically, all histiocytes were positive for CD68, none of which expressed CD1a, although 2 cases focally expressed weak S-100 stain. In 2 cases,BRAF V600E mutation was detected.</p><p><b>CONCLUSIONS</b>ECD is a rare disease of xanthogranulomatous histiocytosis.Its diagnosis relies on pathological and immunohistochemical findings, but correlation with clinical information, especially radiographic findings should be performed.No effective treatment of the disease is currently available.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Antígenos de Diferenciação Mielomonocítica
/
Proteínas S100
/
Antígenos CD
/
Resultado do Tratamento
/
Antígenos CD1
/
Doença de Erdheim-Chester
/
Diagnóstico Diferencial
/
Alergia e Imunologia
/
Genética
Tipo de estudo:
Estudo diagnóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2014
Tipo de documento:
Artigo
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