Hepatic epithelioid angiomyolipoma: a clinicopathologic analysis of 25 cases / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 685-689, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-304417
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic features, immunophenotype, histological diagnosis and prognosis of hepatic epithelioid angiomyolipoma.</p><p><b>METHODS</b>Clinical data of 25 cases of hepatic epithelioid angiomyolipoma were collected along with follow-up study of the patients. The pathological features were documented and immunohistochemical study of various markers was performed with an emphasis on diagnosis and differential diagnosis.</p><p><b>RESULTS</b>Hepatic epithelioid angiomyolipoma was more commonly found in young women without characteristic clinical symptoms. Its morphological features were characterized by marked cytological atypia, relatively rare mitotic figures; radial distribution of tumor cells around the thin-walled blood vessels or muscular vessels; and the presence of common multinucleated giant cells and large ganglion-like tumor cells. The tumor cells expressed both melanoma cell markers (HMB45, MART-1) and smooth muscle cell markers (SMA). Tumor cells expressed various other markers including ER 16% (4/25), PR 32% (8/25), TFE3 24% (6/25) and p53 60% (15/25).</p><p><b>CONCLUSIONS</b>Hepatic epithelioid angiomyolipoma has variable morphological features and characteristic immunohistochemical phenotype. The differential diagnoses include a variety of tumors. The biological behavior of the tumor tends to be benign.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Imuno-Histoquímica
/
Biomarcadores Tumorais
/
Células Gigantes
/
Seguimentos
/
Imunofenotipagem
/
Fatores Etários
/
Angiomiolipoma
/
Diagnóstico Diferencial
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2014
Tipo de documento:
Artigo
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