Immune activity of heat shock protein gp96 and its application in active immunotherapy for tumor and infectious diseases / 生物工程学报
Chinese Journal of Biotechnology
; (12): 261-266, 2012.
Article
em Zh
| WPRIM
| ID: wpr-304495
Biblioteca responsável:
WPRO
ABSTRACT
Heat-shock protein gp96 associates with antigenic peptides derived from tumor and virus. Exogenous gp96-peptide complexes are taken up by antigen-presenting cells through interaction with its receptor CD91 on the cell surface, and cross-present antigenic peptides to MHC class I molecules by a peptide relay line in the endoplasmic reticulum for specific T-cell activation. Meanwhile, gp96 has been shown to initiate innate immune responses through interaction with toll-like receptor 2 and toll-like receptor 4. Recent studies have shown a gp96-mediated immune balance between CTL and Tregs. With the further understanding of counteracting immunosuppressive mechanisms in gp96-induced cellular immune responses, and establishment of high level production of recombinant gp96 by the yeast, gp96 appears to be a promising candidate for designing effective therapeutic vaccines against tumor and infectious diseases.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Terapêutica
/
Doenças Transmissíveis
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Imunoterapia Ativa
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Linfócitos T Reguladores
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Usos Terapêuticos
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Alergia e Imunologia
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Proteínas de Choque Térmico
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Métodos
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Neoplasias
Limite:
Animals
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2012
Tipo de documento:
Article