Plant-specific type III polyketide synthases superfamily: crystal structures and functions / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1-14, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-304518
ABSTRACT
Plant type III polyketide synthase (PKS) generates backbones of a variety of plant secondary metabolites with diverse functions, and has long been models to elucidate the relationship between the three-dimensional structure and function. More than 80 type IIII PKS crystal structures with different functions have been reported in Protein Data Bank, including the crystal structures of the well-studied Chalcone Synthase of plant type III PKS, as well as the 6 other kinds of PKSs in the family, which are critical for understanding the structural basis for diverse starter molecule selectivity, polyketide chain length and the cyclization reaction. Structure-based analysis and site-directed mutagenesis are foundation for the investigation of enzyme engineering, genetic and metabolic engineering. This review summarized 7 plant-specific type III PKS in the aspects of their crystal structures and functions.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Proteínas de Plantas
/
Plantas
/
Especificidade por Substrato
/
Aciltransferases
/
Dados de Sequência Molecular
/
Catálise
/
Engenharia Genética
/
Química
/
Sequência de Aminoácidos
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2012
Tipo de documento:
Artigo
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