FSH and FSHR gene polymorphisms and male infertility: An update / 中华男科学杂志
National Journal of Andrology
;
(12): 1031-1034, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-304776
ABSTRACT
Follicle-stimulating hormone (FSH) is synthesized and secreted by the anterior pituitary, which binds to its receptors expressed on the membrane of Sertoli cells in the testis to bring about spermatogenesis. With the development of DNA sequencing technology, FSH SNPs rs10835638 and FSHR SNPs rs6165, rs6166, and rs1394205 were detected, which might directly affect the expression of FSH and activity of FSHR, resulting in male spermatogenic dysfunction. This review focuses on the relationship of FSH and FSHR gene polymorphisms with male infertility.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células de Sertoli
/
Espermatogênese
/
Testículo
/
Receptores do FSH
/
Polimorfismo de Nucleotídeo Único
/
Hormônio Foliculoestimulante
/
Genética
/
Infertilidade Masculina
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2015
Tipo de documento:
Artigo
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