Preliminary investigation on polymorphs of two traditional Chinese medicine reference substances / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3245-3248, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-304824
ABSTRACT
Crystal structures of chemical drugs has been being investigated widely. But few attention has been paid to polymorphs-phenomena of active ingredients from Traditional Chinese Medicine(TCM). Taking anhydrous dehydroandrographolide and hydrousprim-O-glucosylcimifugin as example, differences between TCM reference substances (RSs) with different crystal structures were discussed by using microscopy, melting point determination, differential thermal analysis (DTA) and infrared (IR) methods. The results showed that different crystal structures could lead to change of melting points, thermal behaviors and IR spectrum. It's indicated that polymorphs may be considered if different physicochemical properties were obtained when applying TCM RS. Differences of chemical properties of active ingredients from TCM with different crystal structures need further investigation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Padrões de Referência
/
Espectrofotometria Infravermelho
/
Medicamentos de Ervas Chinesas
/
Estrutura Molecular
/
Química
/
Cristalização
/
Temperatura de Transição
/
Análise Diferencial Térmica
/
Medicina Tradicional Chinesa
/
Métodos
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Artigo
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