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Clinical implications of relationship between myeloperoxidase and acute coronary syndromes / 中华心血管病杂志
Chinese Journal of Cardiology ; (12): 241-244, 2007.
Artigo em Chinês | WPRIM | ID: wpr-304930
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical implications of relationship between myeloperoxidase and acute coronary syndromes (ACS).</p><p><b>METHODS</b>176 consecutive patients who underwent coronary angiography for coronary atherosclerosis were divided into four groups according to the quartile of MPO Level. The characters and the relationship between MPO and the elements were studied in every group.</p><p><b>RESULTS</b>(1) ACS rate (36.2%) in the fourth quartile group of MPO level was 6 times higher than that (5.2%) in the first quartile group of MPO level, P < 0.01. (2) Gensini score (65.6 +/- 30.3) in the fourth quartile group of MPO level was significantly higher than that (17.3 +/- 10.2) in the first quartile group (P < 0.01). WBC [(7.7 +/- 1.6) x 10(9)/L] in the fourth quartile group was also significantly higher than that [(6.6 +/- 1.8) x 10(9)/L] in the first quartile group, P < 0.05. (3) When TnI < or = 0.05 ng/ml, MPO level had a positive correlation with Gensini score (r = 0.321, P = 0.002) and WBC (r = 0.230, P = 0.025). (4) Kaplan-meier event rate curve showed that there was a significant difference of the terminus incident (death, no causing death AMI, vessel reestablish and incidence rate of CABG add up) between the groups > or = 62.9 AUU/L and < 62.9 AUU/L of MPO serum level at 6-month follow-up visit (chi(2) = 13.5, P = 0.01).</p><p><b>CONCLUSION</b>Activity level of MPO in human serum seems a good biomarker for diagnosing and predicting ACS, which may be especially helpful in predicting the risk of myocardial infarction in patients with acute chest pain during 6-month follow up.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sangue / Diagnóstico por Imagem / Seguimentos / Angiografia Coronária / Isquemia Miocárdica / Peroxidase / Troponina I / Síndrome Coronariana Aguda / Angina Instável / Metabolismo Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Cardiology Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sangue / Diagnóstico por Imagem / Seguimentos / Angiografia Coronária / Isquemia Miocárdica / Peroxidase / Troponina I / Síndrome Coronariana Aguda / Angina Instável / Metabolismo Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Cardiology Ano de publicação: 2007 Tipo de documento: Artigo