Study on retreatment of CHC patients with initial treatment failure / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 304-306, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-305051
ABSTRACT
<p><b>OBJECTIVE</b>To explore the retreatment of CHC patients with initial treatment failure and how to achieve SVR.</p><p><b>METHODS</b>54 patients who had experienced treatment failure were enrolled and retreated with standard treatment of pegylated interferon and ribavirin or intensive treatment, respectively. Their SVR rates were statistically compared, to decide two therapies' application.</p><p><b>RESULTS</b>54 patients had been retreated, and total SVR rate was up to 75.92%, with 88.46% in relapsed patients and 64.29% in non-responders. After retreatment with pegylated interferon and ribavirin, SVR rate was 95.45% in patients with prior interferon monotherapy, and 64.71% in patients with prior interferon and ribavirin, and 60% in patients with prior pegylated interferon alpha-2a monotherapy. SVR rate of relapsed patients was significantly higher than that of non-responders.</p><p><b>CONCLUSIONS</b>In CHC patients with treatment failure, SVR rate of retreatment with standard treatment or intensive treatment still can be up to 60%-90%. Retreatment with standard therapy can be applied to patients who had received interferon monotherapy or interferon plus ribavirin. Three types of patients who need intensive retreatment were as following patients nonresponsive to interferon plus ribavirin or pegylated interferon alpha-2a monotherapy, and patients with treatment failure who had received prior standard treatment.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Fisiologia
/
Polietilenoglicóis
/
Ribavirina
/
Virologia
/
Proteínas Recombinantes
/
Interferon-alfa
/
Falha de Tratamento
/
Hepacivirus
/
Retratamento
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2012
Tipo de documento:
Artigo
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