Correlationship between chemokines and oxidative stress in chronic hepatitis B / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 246-249, 2012.
Article
em Zh
| WPRIM
| ID: wpr-305069
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The aim of this study is to investigate the possible associations of chemokines IP-10, Rantes and oxidative stress in chronic hepatits B (CHB).</p><p><b>METHODS</b>70 CHB patients and 10 healthy controls were enrolled in the study. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of IFN-gamma-inducible protein-10 (IP-10) and regulated on activation normal T-cell-expressed and secreted (Rantes) and oxidative stress parameters (glutathione, GSH; glutathione disulfide, GSSG). Correlationship were analyzed by Spearman's rank correlation.</p><p><b>RESULT</b>The levels of IP-10 and Rantes were higher in CHB patients than healthy controls, and strong positive associations were found between IP-10/Rantes and alanine aminotransferase (ALT). The levels of GSH and GSH/GSSG were lower in CHB patients than healthy controls, and GSH and GSH/GSSG were negatively correlated with ALT. The levels of IP-10 and Rantes were negatively correlated with GSH and GSH/GSSG respectively.</p><p><b>CONCLUSION</b>Strong associations were found between chemokines and oxidative stress which participated in the pathogenesis of CHB.</p>
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Índice:
WPRIM
Assunto principal:
Virologia
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Sangue
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Vírus da Hepatite B
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Estresse Oxidativo
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Quimiocina CCL5
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Hepatite B Crônica
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Dissulfeto de Glutationa
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Alanina Transaminase
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Quimiocina CXCL10
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Genética
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2012
Tipo de documento:
Article