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Determination of serum IL-23 and its significance in patients with severe chronic hepatitis B / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 123-124, 2012.
Artigo em Chinês | WPRIM | ID: wpr-305081
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the level of the serum IL-23 and its correlation with serum biochemical indices of liver function tests and HBV DNA load in patients with chronic severe hepatitis B.</p><p><b>METHODS</b>Fifty patients with chronic severe hepatitis B (severe hepatitis group) and 18 healthy controls (control group) were enrolled in the study. The serum IL-23 expression level was detected by ELISA method. The correlation between IL-23 and ALT, AST, TBil, HBV DNA load was analyzed using Pearson's correlation analysis, respectively.</p><p><b>RESULTS</b>Serum IL-23 expression level in severe hepatitis group was significantly higher than that of control group (P < 0.05). Serum IL-23 level was positively correlated with serum ALT, AST, respectively (P < 0.05), but was not correlated with TBil and HBV DNA load, respectively (P > 0.05).</p><p><b>CONCLUSION</b>Serum IL-23 expression level was increased in patients with chronic severe hepatitis B and was associated with the severe of inflammation. We, therefore, believe that IL-23 might be involved in the pathogenesis of chronic severe hepatitis B.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aspartato Aminotransferases / Virologia / Sangue / DNA Viral / Hepatite B Crônica / Alanina Transaminase / Alergia e Imunologia / Interleucina-23 Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aspartato Aminotransferases / Virologia / Sangue / DNA Viral / Hepatite B Crônica / Alanina Transaminase / Alergia e Imunologia / Interleucina-23 Limite: Adulto / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2012 Tipo de documento: Artigo