Expressions of integrinalpha2beta1 and CD133 in benign prostatic hyperplasia complicated by prostatitis and their significance / 中华男科学杂志
National Journal of Andrology
;
(12): 909-912, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-305765
ABSTRACT
<p><b>OBJECTIVE</b>To study the expressions of Integrinalpha2beta1 and CD133 in benign prostatic hyperplasia (BPH) complicated by prostatitis and their significance.</p><p><b>METHODS</b>Specimens were obtained from 56 BPH patients undergoing transvesical prostatectomy. Paraffin sections of the specimens were subjected to HE staining for pathological examination of inflammatory changes under the light microscope. Twenty-four patients with simple BPH were included in Group A, and the other 32 with BPH complicated with prostatitis in Group B. The expressions of Integrinalpha2beta1 and CD133 in the prostatic tissues of the two groups were determined by immunohistochemistry, Western blotting and IPP6.0 image analysis software.</p><p><b>RESULTS</b>The expressions of Integrinalpha2beta1 and CD133 were significantly higher in Group B than in A (P < 0.05), and so were the mean relative value of the optical density of Integrinalpha2beta1 (0.29 +/- 0.18 vs 0.04 +/- 0.03) and that of CD133 (0.08 +/- 0.07 vs 0.0020 +/- 0.0018) (P < 0.05).</p><p><b>CONCLUSION</b>Inflammation can up-regulate the expressions of Integrinalpha2beta1 and CD133 in BPH tissue.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Peptídeos
/
Hiperplasia Prostática
/
Prostatite
/
Glicoproteínas
/
Antígenos CD
/
Integrina alfa2beta1
/
Antígeno AC133
/
Inflamação
/
Metabolismo
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2011
Tipo de documento:
Artigo
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