Relationship between vitamin D receptor gene Fok I polymorphisms and benign prostatic hyperplasia complicated by histological prostatitis / 中华男科学杂志
National Journal of Andrology
;
(12): 880-883, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-305772
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between vitamin D receptor (VDR) gene Fok I polymorphisms and BPH complicated by histological prostatitis (BPH + HP).</p><p><b>METHODS</b>We detected Fok I polymorphisms in the peripheral blood of 79 patients with BPH + HP and 81 controls with BPH only using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and analyzed the frequency distribution of the genotypes and alleles of the two groups of patients.</p><p><b>RESULTS</b>Obvious differences were found in the distribution of genotypes and alleles between the BPH + HP patients (FF 27% [21/79], Ff 30% [24/79], ff 43% [34/79]) and the controls (FF 33% [27/81], Ff 36% [29/81], ff 31% [25/81]), with statistical significance in the distribution of the genotype ff (P < 0.05). The histological prostatitis group showed a significant difference from the controls in the frequency of the f allele (58% [196/338] vs 49% [153/312], P < 0.05), but not in that of the F allele (42% [142/338] vs 51% [159/312] , P > 0.05).</p><p><b>CONCLUSION</b>VDR Fok I polymorphisms may be correlated with BPH complicated by histological prostatitis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hiperplasia Prostática
/
Prostatite
/
Estudos de Casos e Controles
/
Reação em Cadeia da Polimerase
/
Receptores de Calcitriol
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Alelos
/
Frequência do Gene
/
Genética
Tipo de estudo:
Estudo observacional
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2011
Tipo de documento:
Artigo
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