Neuregulin promotes spermatogonia proliferation in mice / 中华男科学杂志
National Journal of Andrology
;
(12): 406-409, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-305820
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of neuregulin (neural regulation of protein, NRG) in the process of mouse spermatogonia proliferation.</p><p><b>METHODS</b>Mouse testis fragments were cultured in the medium DMEM containing purified NRG1beta or NRG3 at the concentration of 50, 100 and 200 ng/ml, respectively, followed by BrdU immunohistochemical staining and determination of the proliferation rate of spermatogonia.</p><p><b>RESULTS</b>Compared with the control group, neuregulin significantly promoted the proliferation of spermatogonia (P < 0.05). The proliferation rates of spermatogonia cultured in the medium with 50, 100 and 200 ng/ml of NRG13 were 1.69, 1.55 and 1.86 times, and those with 50, 100 and 200 ng/ml of NRG3 were 1.35, 1.54 and 2.11 times that of the control.</p><p><b>CONCLUSION</b>NRG1beta and NRG3 can promote the proliferation of mouse spermatogonia, and NRG is expected to be applied in the treatment of male infertility.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Espermatogônias
/
Transdução de Sinais
/
Células Cultivadas
/
Neuregulina-1
/
Biologia Celular
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Proliferação de Células
/
Metabolismo
/
Camundongos Endogâmicos C57BL
Limite:
Animais
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2011
Tipo de documento:
Artigo
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