Proteomics study of papillary thyroid carcinoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 465-470, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-305974
ABSTRACT
<p><b>OBJECTIVE</b>To study the proteomics of papillary thyroid carcinoma (PTC), and to detect the differential expression of proteins compared to normal thyroid (NT) tissue.</p><p><b>METHODS</b>Protein extracts of papillary thyroid carcinoma and normal thyroid tissues from 10 patients were separated by proteomics technique and identified using Image Master software. The selected differential proteins were sent to Proteomics Research Center of Chinese Academy of Medical Sciences for mass-spectrometry identification.</p><p><b>RESULTS</b>The basic 2-dimensional electrophoresis (2-DE) images of PTC and NT were obtained, and four potential differential expression spots were selected for mass-spectrometry identification. Among them, annexin I, peroxiredoxin I, mitochondrial aconitase were up-regulated while carbonic anhydrase I was down-regulated.</p><p><b>CONCLUSION</b>Proteomics may provide a new direction to study PTC, by identifying some tumor-specific markers, leading to elucidation of the mechanism of tumorigenesis and identification of therapeutic targets.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Glândula Tireoide
/
Neoplasias da Glândula Tireoide
/
Carcinoma Papilar
/
Biomarcadores Tumorais
/
Regulação para Baixo
/
Regulação Neoplásica da Expressão Gênica
/
Regulação para Cima
/
Química
/
Proteômica
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2008
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS