Expression of nuclear export factor CRM1 and p27 in glioma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 454-457, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-305976
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of nuclear export factor CRM1, Ser10-phosphorylated p27 and p27 in human gliomas.</p><p><b>METHODS</b>The expression of CRM1, Ser10-phosphorylated p27 and p27 were investigated in 70 cases of human gliomas and 10 specimens of the normal brain tissue by immunohistochemical technique and Western blot.</p><p><b>RESULTS</b>There were significant differences on the expression levels of CRM1, Ser10-phosphorylated p27 and p27 among normal brain tissue, gliomas of grades II and gliomas of grades III plus IV (P < 0.01). The expression of CRM1 in gliomas was inversely correlated with the expression of p27 (r(s) = -0.727, P < 0.01) and positively correlated with the expression of Ser10-phosphorylated p27 (r(s) = 0.954, P < 0.01) and Ki-67 (r(s) = 0.799, P < 0.01). Moreover, the expression of Ser10-phosphorylated p27 was inversely correlated with p27 (r(s) = -0.744, P < 0.01) and positively correlated with Ki-67 (r(s) = 0.785, P < 0.01).</p><p><b>CONCLUSIONS</b>CRM1, through recognizing and binding with Ser10-phosphorylated p27, may promote moving of p27CRM1 from its original locating sites; act as a critical signaling component in the proliferative process of glioma cells and then, plays an important role in the development of gliomas.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosforilação
/
Prognóstico
/
Neoplasias Encefálicas
/
Regulação Neoplásica da Expressão Gênica
/
Transporte Ativo do Núcleo Celular
/
Sinais de Exportação Nuclear
/
Inibidor de Quinase Dependente de Ciclina p27
/
Genética
/
Glioma
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2008
Tipo de documento:
Artigo
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