Effect of interleukin-8 in cell invasion and proliferation of human breast cancer / 中华外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To identify the effect of interleukin-8 in cell progression and invasion of human breast cancer.</p><p><b>METHODS</b>Human cytokine antibody arrays were applied to screen a panel of cytokine expression from 11 human breast cancer cell lines, and the mechanism of identified key factors involved in breast cancer progression was studied.</p><p><b>RESULTS</b>Profiling of cytokine expression showed the expression of interleukin-8 was related to estrogen receptor status, metastasis and vimentin status in the 11 human breast cancer cell lines. Elevated expression of interleukin-8 in breast cancer cells had positive correlation with breast cancer invasion. Neutralization of antibody against interleukin-8 specifically blocked interleukin-8-mediated cell invasion. However, anti-interleukin-8 antibody did not influence the proliferation of breast cancer cells.</p><p><b>CONCLUSION</b>Interleukin-8 may be the key factor involved in human breast cancer progression and invasion, and play an important role in cell invasion of breast cancer.</p>