The relationship between the C589T polymorphism of IL-4 gene and cholelithiasis / 中华外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between IL-4 gene polymorphism and cholelithiasis in Chinese population.</p><p><b>METHODS</b>Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of IL-4 gene in 81 cholecystolithiasis, 41 patients with biliary duct stone.</p><p><b>RESULTS</b>There were no significant differences of the IL-4 gene polymorphism genotypes and alleles between 81 cholecystolithiasis patients (CC11.1%, CT34.6%, TT54.3%; C28.4.7%, T71.6%). There were significant differences of the IL-4 gene polymorphism genotypes and alleles between 41 patients with biliary duct stone (CC48.8%, CT36.6%, TT14.6%; C67.1%, T32.9%).</p><p><b>CONCLUSIONS</b>The C589T polymorphism of IL-4 gene was not associated with cholecystolithiasis patients in Chinese, but was related to patients with biliary duct stone in Chinese.</p>