Effect of jiantai liquid on expression of estrogen and progesterone receptors in uterus of mice with embryo implantation dysfunction induced by mifepristone / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 816-819, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-306776
ABSTRACT
<p><b>OBJECTIVE</b>To explore the molecular mechanism of jiantai liquid (JTL) in improving endometrial receptivity of mice with embryo implantation dysfunction (EID).</p><p><b>METHODS</b>Mice model of EID induced by mifepristone were intervened with JTL (Twig of Chinese Taxillus, Red Sage root, Chinese Angelica, Milkvetch root, Chuanxiong rhizome), and sacrificed on day 8 of pregnancy. The endometrial estrogen receptor (ER) and progesterone receptor (PR) protein and their gene expressions were assessed by Western blot and semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>Levels of ER and PR protein and their gene expressions in the JTL treated group were significantly higher than those in the model group respectively (all P < 0.05), and showed insignificant difference from those in the normal control group (all P > 0.05).</p><p><b>CONCLUSION</b>JTL could promote the development of endometrium and improve the embryo implantation by way of regulating the levels of ER and PR protein and gene expression in mice with EID.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Implantação do Embrião
/
Farmacologia
/
Útero
/
Medicamentos de Ervas Chinesas
/
Receptores de Progesterona
/
Receptores de Estrogênio
/
Mifepristona
/
Genética
/
Luteolíticos
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2004
Tipo de documento:
Artigo
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