Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the possible relationship between vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphism and warfarin dose requirements in Chinese patients.</p><p><b>METHOD</b>Genotyping for the C1173T polymorphism in the VKORC1 gene was performed using a restriction enzyme digestion of PCR-amplified DNA in 102 Chinese patients treated with warfarin.</p><p><b>RESULTS</b>TT genotype was found in 83 patients (81.4%), CT genotype in 16 patients (15.7%) and CC genotype in 3 patients (2.9%). To achieve similar target INR range (1.5 - 2.5), the warfarin dose requirement was significantly lower in patients with TT genotype than that in patients with CT/CC genotypes (P < 0.01).</p><p><b>CONCLUSION</b>C1173T polymorphism in the VKORC1 gene might be one important determinant for warfarin dose requirement in Chinese patients.</p>