Expression of MICA/B protein in esophageal cancer and its clinical significance / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 745-747, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-307302
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of MICA/B in human esophageal cancer, and to analyze its correlation with clinicopathological features.</p><p><b>METHODS</b>The expression of MICA/B in 40 cases of esophagus carcinoma and corresponding normal esophageal mucosa tissues were examined by immunohistochemistry.</p><p><b>RESULTS</b>The positive rate of expression of MICA/B protein in the esophageal carcinoma was 75.0% (30/40), and that in the corresponding normal esophageal mucosa was 0 (0/40). Up-regulation of MICA/B expression was found in the esophageal carcinomas. The expression of MICA/B was related with histological grade of the esophageal carcinoma (P = 0.012).</p><p><b>CONCLUSION</b>MICA/B protein plays an important role in the esophageal carcinogenesis, and my become a useful molecular marker for the diagnosis of esophageal carcinoma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias Esofágicas
/
Imuno-Histoquímica
/
Antígenos de Histocompatibilidade Classe I
/
Biomarcadores Tumorais
/
Regulação para Cima
/
Diagnóstico
/
Gradação de Tumores
/
Metabolismo
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2012
Tipo de documento:
Artigo
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