Gut Microbiota-brain Axis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2373-2380, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-307409
ABSTRACT
<p><b>OBJECTIVE</b>To systematically review the updated information about the gut microbiota-brain axis.</p><p><b>DATA SOURCES</b>All articles about gut microbiota-brain axis published up to July 18, 2016, were identified through a literature search on PubMed, ScienceDirect, and Web of Science, with the keywords of "gut microbiota", "gut-brain axis", and "neuroscience".</p><p><b>STUDY SELECTION</b>All relevant articles on gut microbiota and gut-brain axis were included and carefully reviewed, with no limitation of study design.</p><p><b>RESULTS</b>It is well-recognized that gut microbiota affects the brain's physiological, behavioral, and cognitive functions although its precise mechanism has not yet been fully understood. Gut microbiota-brain axis may include gut microbiota and their metabolic products, enteric nervous system, sympathetic and parasympathetic branches within the autonomic nervous system, neural-immune system, neuroendocrine system, and central nervous system. Moreover, there may be five communication routes between gut microbiota and brain, including the gut-brain's neural network, neuroendocrine-hypothalamic-pituitary-adrenal axis, gut immune system, some neurotransmitters and neural regulators synthesized by gut bacteria, and barrier paths including intestinal mucosal barrier and blood-brain barrier. The microbiome is used to define the composition and functional characteristics of gut microbiota, and metagenomics is an appropriate technique to characterize gut microbiota.</p><p><b>CONCLUSIONS</b>Gut microbiota-brain axis refers to a bidirectional information network between the gut microbiota and the brain, which may provide a new way to protect the brain in the near future.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Sistema Hipófise-Suprarrenal
/
Encéfalo
/
Sistema Nervoso Central
/
Trato Gastrointestinal
/
Microbioma Gastrointestinal
/
Sistema Hipotálamo-Hipofisário
/
Metabolismo
/
Microbiologia
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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