Pathogenesis and Individualized Treatment for Postural Tachycardia Syndrome in Children / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2241-2245, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-307435
ABSTRACT
<p><b>OBJECTIVE</b>Postural tachycardia syndrome (POTS) is one of the major causes of orthostatic intolerance in children. We systematically reviewed the pathogenesis and the progress of individualized treatment for POTS in children.</p><p><b>DATA SOURCES</b>The data analyzed in this review are mainly from articles included in PubMed and EMBASE.</p><p><b>STUDY SELECTION</b>The original articles and critical reviews about POTS were selected for this review.</p><p><b>RESULTS</b>Studies have shown that POTS might be related to several factors including hypovolemia, high catecholamine status, abnormal local vascular tension, and decreased skeletal muscle pump activity. In addition to exercise training, the first-line treatments mainly include oral rehydration salts, beta-adrenoreceptor blockers, and alpha-adrenoreceptor agonists. However, reports about the effectiveness of various treatments are diverse. By analyzing the patient's physiological indexes and biomarkers before the treatment, the efficacy of medication could be well predicted.</p><p><b>CONCLUSIONS</b>The pathogenesis of POTS is multifactorial, including hypovolemia, abnormal catecholamine state, and vascular dysfunction. Biomarker-directed individualized treatment is an important strategy for the management of POTS children.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Terapêutica
/
Catecolaminas
/
Agonistas alfa-Adrenérgicos
/
Antagonistas Adrenérgicos beta
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Síndrome da Taquicardia Postural Ortostática
/
Metabolismo
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS