Studies on preparation of sinomenine hydrochloride-loaded bovine serum albumin microspheres / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2131-2134, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-307496
ABSTRACT
<p><b>OBJECTIVE</b>To prepare Sinomenine hydrochloride-loaded bovine serum albumin microspheres (SM-BSA-MS).</p><p><b>METHOD</b>SM-BSA-MS was prepared by spray drying technique. The morphology, drug-loading and release in vitro of SM-BSA-MS was studied.</p><p><b>RESULT</b>The diameters of SM-BSA-MS were in the range of 1-3 m. The drug loading of microspheres, formulated with different drug/albumin ratios as 1, 2, 11, 21, were 31.6%, 47.7% and 67.9% , respectively. And the drug entrapment efficiencies of different drug/albumin ratios were higher than 94%. The results of in vitro release experiments showed that the drug loaded microspheres have the properties of sustained-release compared with the Sinomenine hydrochloride injection. Different release characteristics could be obtained by adjusting the prescription composition and the thermal denaturation condition.</p><p><b>CONCLUSION</b>Spray drying technique is a simple and feasible method for preparing SM-BSA-MS. The drug loaded microspheres had high drug-loading and sustained-release effect.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Plantas Medicinais
/
Soroalbumina Bovina
/
Portadores de Fármacos
/
Química
/
Sinomenium
/
Preparações de Ação Retardada
/
Composição de Medicamentos
/
Métodos
/
Microesferas
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Artigo
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