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Nephrotoxicity of Radix Aristolochice and it's substitution material Radix Inulae in rats / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2048-2051, 2007.
Artigo em Chinês | WPRIM | ID: wpr-307533
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the toxicity of Radix Aristolochiae and Radix Inulae, and to supply the toxicity experimental data that Radix Inulae supersedes Radix Aristolochiae in clinic.</p><p><b>METHOD</b>A long dose of Radix Aristolochice and Radix Inulae was given intragastrically to rats for six months, then drug withdrawal for a month. The hematology and biochemical indicators were measured, and the pathologic changes of kidney, liver, stomach and urinary bladder were examined.</p><p><b>RESULT</b>The rats of Radix Aristolochice showed serious toxic responses of renal tubule atrophy and necrosis, meanwhile, the levels of BUN, Cr and NAG were increased obviously. Hepatonecrosis, renal tubular necrosis, gastric carcinoma and bladder carcinoma were discovered with pathologic assaying. But the rats of Radix Inulae did not.</p><p><b>CONCLUSION</b>Radix Aristolochiae could damage kidney and liver, and cause gastric carcinoma and bladder carcinoma by intensive toxicity. Radix Inulae could take the place of Radix Aristolochiae to use in clinic.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Plantas Medicinais / Acetilglucosaminidase / Estômago / Neoplasias Gástricas / Urina / Bexiga Urinária / Neoplasias da Bexiga Urinária / Sangue / Nitrogênio da Ureia Sanguínea Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Plantas Medicinais / Acetilglucosaminidase / Estômago / Neoplasias Gástricas / Urina / Bexiga Urinária / Neoplasias da Bexiga Urinária / Sangue / Nitrogênio da Ureia Sanguínea Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2007 Tipo de documento: Artigo