Studies on bioassay-guided anti-inflammatory fraction in bark of Albizia julibrissin combined determination with LC-MS-MS / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2021-2025, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-307539
ABSTRACT
<p><b>OBJECTIVE</b>To search the anti-inflammatory fraction of Albizia julibrissin.</p><p><b>METHOD</b>Inflammatory model of Kunming mice ear edema induced by croton oil and determination combined with the LC-MS-MS-guided fractionation and isolation were used.</p><p><b>RESULT</b>The n-butanol fraction (AJ-B) obtained from the ethanolic extract of the Cortex albiziae was the major active fraction. The lignan glycosides fraction (AJ-B-1), which was further isolated from AJ-B, showed significant anti-inflammatory activity and exhibited dose-dependent relationship in the dose of 5 to 20 mg x kg(-1).</p><p><b>CONCLUSION</b>The method of bioassay-guided fractionation and isolation combined with the LC-MS-MS determination may be of benefit to the logical studies on the bioactive fractions or constituents of traditional Chinese materia medica.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas Medicinais
/
Bioensaio
/
Óleo de Cróton
/
Medicamentos de Ervas Chinesas
/
Química
/
Anti-Inflamatórios não Esteroides
/
Cromatografia Líquida de Alta Pressão
/
Lignanas
/
Casca de Planta
/
Albizzia
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Artigo
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