In vitro evaluation of self-emulsifying drug delivery system of volatile oil from rhizome of Ligusticum chuanxiong / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2003-2007, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-307544
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the evaluation method for self-emulsifying drug delivery system of volatile oil from rhizome of Ligusticum chuanxiong (VOC SEDDS).</p><p><b>METHOD</b>The self-emulsifying ability, the efficiency of self-emulsification, the properties of emulsion, the dissolution of volatile oil from Rhizome of Ligusticum Chuanxiong and the stability of the emulsion were determined.</p><p><b>RESULT</b>The optimized formulation can fully emulsify in 5 min and the particle sizes were around 102 nm. Zeta potential was about -30 mV. The O/W emulsions were stable through centrifugation with high reproducibility. In vitro dissolution test indicated that over 80% of drug dissolved in 30 min and VOC SEDDS was stable under light and high temperature in 10 d.</p><p><b>CONCLUSION</b>VOC SEDDS has strong self-emulsifying ability, fine stability and high dissolution rate in vitro.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Plantas Medicinais
/
Solubilidade
/
Tensoativos
/
Temperatura
/
Fatores de Tempo
/
Óleos Voláteis
/
Química
/
Sistemas de Liberação de Medicamentos
/
Ligusticum
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Artigo
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