Aporphine alkaloids from branches and leaves of Polyalthia nemoralis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2343-2345, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-307588
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the aporphine alkaloids in the branches and leaves of Polyalthia nemoralis.</p><p><b>METHOD</b>The compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatographies. Their chemical structures were elucidated on the basis of physicochemical properties and spectral data.</p><p><b>RESULT</b>Five aporphine alkaloids were isolated and identified as bidebiline A (1), annobraine (2), lanuginosine (3), liriodenine (4), oxostephanosine (5), respectively.</p><p><b>CONCLUSION</b>For the first time, Compounds 2 and 5 were obtained from Polyalthia while 1, 3 and 4 isolated from this plant. The bioassays in vitro against five human tumor cell lines with MTT method showed moderate cytotoxic activities (IC50 1 mg x L(-1)) of compounds 3-5.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aporfinas
/
Farmacologia
/
Química
/
Caules de Planta
/
Folhas de Planta
/
Polyalthia
/
Linhagem Celular Tumoral
/
Antineoplásicos Fitogênicos
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2009
Tipo de documento:
Artigo
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