Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced ventricular arrhythmias in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 578-581, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-307881
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of fluvastatin on lysophosphatidylcholine (LPC)-induced ventricular arrhythmias and its mechanism.</p><p><b>METHODS</b>Twenty male SD rats were randomly allocated into two equal groups, namely LPC treatment group and fluvastatin pretreatment group. Langendorff apparatus was used for cardiac perfusion ex vivo with 5 µmol/L LPC for 5 min followed by washing for 30 min in LPC treatment group, and in fluvastatin pretreatment group, a 30-min perfusion with 10 µmol/L fluvastatin was administered before LPC perfusion. The LPC-induced nonselective cation current (I(NSC)) in the ventricular myocytes was recorded using the whole-cell voltage-clamp method.</p><p><b>RESULTS</b>Fluvastatin significantly inhibited LPC-induced ventricular tachyarrhythmia/fibrillation and I(NSC). The small G-protein Rho inhibitor (C3) and Rho-kinase inhibitor (Y-27632) in the pipette solution also suppressed LPC-induced I(NSC).</p><p><b>CONCLUSION</b>Fluvastatin offers cardiac protection against LPC by inhibiting LPC-induced I(NSC). LPC induces fatal arrhythmia via a Rho/Rho-kinase-mediated pathway.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Arritmias Cardíacas
/
Ácidos Graxos Monoinsaturados
/
Lisofosfatidilcolinas
/
Ratos Sprague-Dawley
/
Miócitos Cardíacos
/
Antagonismo de Drogas
/
Quinases Associadas a rho
/
Indóis
/
Canais Iônicos
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2011
Tipo de documento:
Artigo
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