Mutations in exon 19 of EGFR gene in non-small cell lung cancer from Chinese patients / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 315-318, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-308069
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mutations in exon 19 of epidermal growth factor receptor (EGFR) gene in non-small cell lung cancer from Chinese patients.</p><p><b>METHODS</b>Genomic DNA was extracted from 72 lung cancer tissues. Then the exon 19 of EGFR gene was amplified by nested PCR and sequenced.</p><p><b>RESULTS</b>In 13 tumor tissues, multi-nucleotide in-frame deletion mutations at the exon 19 of EGFR gene, had been detected. There were 4 mutation types. The mutation rate was 18.1%. The mutations were all heterozygous. There was association of the exon 19 mutation of EGFR gene with adenocarcinoma, female patients and non-smokers.</p><p><b>CONCLUSION</b>There were multi-nucleotide in-frame deletion mutations in exon 19 of EGFR gene. Mutations of the exon 19 of EGFR gene were higher in female, non-smoking and adenocarcinoma patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Análise Mutacional de DNA
/
Adenocarcinoma
/
Fumar
/
Fatores Sexuais
/
Reação em Cadeia da Polimerase
/
Éxons
/
Carcinoma Pulmonar de Células não Pequenas
/
Genes erbB-1
/
Genética
/
Mutação
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2008
Tipo de documento:
Artigo
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