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Mutations in exon 19 of EGFR gene in non-small cell lung cancer from Chinese patients / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 315-318, 2008.
Artigo em Chinês | WPRIM | ID: wpr-308069
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mutations in exon 19 of epidermal growth factor receptor (EGFR) gene in non-small cell lung cancer from Chinese patients.</p><p><b>METHODS</b>Genomic DNA was extracted from 72 lung cancer tissues. Then the exon 19 of EGFR gene was amplified by nested PCR and sequenced.</p><p><b>RESULTS</b>In 13 tumor tissues, multi-nucleotide in-frame deletion mutations at the exon 19 of EGFR gene, had been detected. There were 4 mutation types. The mutation rate was 18.1%. The mutations were all heterozygous. There was association of the exon 19 mutation of EGFR gene with adenocarcinoma, female patients and non-smokers.</p><p><b>CONCLUSION</b>There were multi-nucleotide in-frame deletion mutations in exon 19 of EGFR gene. Mutations of the exon 19 of EGFR gene were higher in female, non-smoking and adenocarcinoma patients.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Análise Mutacional de DNA / Adenocarcinoma / Fumar / Fatores Sexuais / Reação em Cadeia da Polimerase / Éxons / Carcinoma Pulmonar de Células não Pequenas / Genes erbB-1 / Genética / Mutação Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Análise Mutacional de DNA / Adenocarcinoma / Fumar / Fatores Sexuais / Reação em Cadeia da Polimerase / Éxons / Carcinoma Pulmonar de Células não Pequenas / Genes erbB-1 / Genética / Mutação Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2008 Tipo de documento: Artigo