Early diagnosis of prostate cancer using free/total prostate-specific antigen ratio with population-based screening data / 中华男科学杂志
National Journal of Andrology
;
(12): 582-585, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-308296
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the use of free/total prostate-specific antigen ratio (fPSA/tPSA ratio) in improving the early diagnosis of prostate cancer.</p><p><b>METHODS</b>fPSA/tPSA ratio in the serum was analyzed prospectively in 187 men with tPSA ranging between 4.0 and 20.0 microg/L. All of them underwent ultrasound-guided sextant prostatic biopsies. Sensitivity, specificity, positive and negative predictive values were calculated by SPSS 10.0 software.</p><p><b>RESULTS</b>Prostate cancer detection rates were 18.1% and 22.5% when tPSA was within the ranges of 4.0-10.0 g/L and 10.0-20.0 g/L respectively. fPSA/tPSA ratio was more significant than tPSA in all the men. When the cut-off value of fPSA/tPSA ratio was set at 0.25, 90.5% and 87.5% of cancers could be detected; and 26.7% and 11.3% of biopsies could be avoided within the tPSA ranges of 4.0-10.0 g/L and 10.0-20.0 g/L, respectively.</p><p><b>CONCLUSION</b>The use of fPSA/tPSA ratio can improve prostate cancer detection and reduce unnecessary biopsies when tPSA is within the range of 4.0-10.0 microg/L and 10.0-20.0 microg/L.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias da Próstata
/
Sangue
/
Programas de Rastreamento
/
Estudos Prospectivos
/
Sensibilidade e Especificidade
/
Antígeno Prostático Específico
/
Área Sob a Curva
/
Diagnóstico Precoce
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Idoso
/
Aged80
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2004
Tipo de documento:
Artigo
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