Phospholipase C and reproduction / 中华男科学杂志
National Journal of Andrology
;
(12): 538-542, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-308303
ABSTRACT
Phospholipase C (PLC) is a key enzyme in phosphatidyl inositol turnover during signal transduction. The 12 mammalian PLC isozymes identified to date can be divided into five subtypes, beta-type, gamma-type, delta-type, epsilon-type and zeta-type, with extensive difference in structure, regulatory mechanism and tissue distribution. PLC plays important roles not only in sperm acrosome reaction but also in egg activation. The present studies are reviewed on the structure, regulation and function of PLC, especially its function in male reproduction, including triggering Ca2+ oscillations in eggs to activate the eggs and helping embryo development. And the prospect of the clinical application of PLC is discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfolipases Tipo C
/
Fisiologia
/
Reprodução
/
Transdução de Sinais
/
Química
/
Sinalização do Cálcio
/
Reação Acrossômica
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2004
Tipo de documento:
Artigo
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