Significance of EGFR and p-ERK expression in nasopharyngeal carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 28-31, 2006.
Article
em Zh
| WPRIM
| ID: wpr-308429
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of EGFR and p-ERK in nasopharyngeal carcinoma (NPC) and investigate their clinical significance.</p><p><b>METHODS</b>Immunohistochemistry LSAB method was adopted to detect the expression of EGFR and p-ERK. Statistical analysis was performed using SPSS statistical software package (10.0) to correlate their expression with clinical characteristics and prognosis.</p><p><b>RESULTS</b>Positive staining for EGFR was observed in 39 of 55 cases (70.9%). The EGFR expression was correlated with clinical stage and gender. EGFR expression was correlated with poorer overall survival (OS) and shorter time to progression (TTP). Positive staining for p-ERK was observed in 29 of 55 cases (52.7%). There was a statistically significant association between positive p-ERK expression and advanced clinical stage. Positive p-ERK expression was correlated with poorer OS, disease-free survival (DFS) and TTP. EGFR expression was correlated with the expression of p-ERK. On multivariate analysis, age over 50 years was an independent poor prognostic factor for NPC. Both EGFR and p-ERK were not independent prognostic factors for NPC.</p><p><b>CONCLUSION</b>Expressions of EGFR and p-ERK are detected in NPC. Their abnormally high expression signifies poor prognosis in NPC patients.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
/
Modelos de Riscos Proporcionais
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Fatores Sexuais
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Neoplasias Nasofaríngeas
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Taxa de Sobrevida
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Seguimentos
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Fatores Etários
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Intervalo Livre de Doença
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Proteínas Quinases Ativadas por Mitógeno
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Receptores ErbB
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Female
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Humans
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2006
Tipo de documento:
Article