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Association of genetic polymorphism in the DNA repair gene XRCC1 with susceptibility to lung cancer in non-smoking women / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 713-716, 2005.
Artigo em Chinês | WPRIM | ID: wpr-308456
ABSTRACT
<p><b>OBJECTIVE</b>To assess the relationship between the XRCC1 polymorphism and susceptibility to lung cancer in non-smoking female on the basis of a hospital-based case-control study.</p><p><b>METHODS</b>Genotypes were determined by PCR-restriction fragment length polymorphism in 50 patients with lung cancer and 50 controls. The adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression model to study the relationship between different genotypes and risk of lung cancer in non-smoking women. Furthermore, a multiplicative interaction between exposure to cooking oil smoke and the variant XRCC1 399Gln allele on risk of lung adenocarcinoma was evaluated.</p><p><b>RESULTS</b>Individuals carrying Gln/Gln genotype were at an increased risk to suffer from lung adenocarcinoma as compared with those with the Arg/Arg genotype (OR 14.12; 95% CI 2.14 approximately 92.95, adjusted for age and cooking oil smoke). The OR of lung adenocarcinoma for the variant XRCC1 399Gln allele with exposure to cooking oil smoke was 6.29 (95% CI 1.99 approximately 19.85).</p><p><b>CONCLUSION</b>The above described findings indicate that Arg 399Gln polymorphism in the XRCC1 is associated with risk of lung adenocarcinoma but not with risk of squamous-cell carcinoma of the lung in non-smoking women.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Carcinoma de Células Escamosas / Adenocarcinoma / Fumar / Estudos de Casos e Controles / Poluição do Ar em Ambientes Fechados / Medição de Risco / Culinária / Predisposição Genética para Doença / Proteínas de Ligação a DNA Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco Limite: Adulto / Idoso / Feminino / Humanos Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Carcinoma de Células Escamosas / Adenocarcinoma / Fumar / Estudos de Casos e Controles / Poluição do Ar em Ambientes Fechados / Medição de Risco / Culinária / Predisposição Genética para Doença / Proteínas de Ligação a DNA Tipo de estudo: Estudo de etiologia / Estudo observacional / Fatores de risco Limite: Adulto / Idoso / Feminino / Humanos Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2005 Tipo de documento: Artigo