Stable life predection of Hangbaiju and Gongju by classic constant temperature accelerated test method / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the stability of chlorogenic acid, cynaroside and 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju and to predict their term of validity.</p><p><b>METHOD</b>Hangbaiju and Gongju were incubated in an environmental chamber at different temperatures and relative humidities. After the incubation, quantitative determination of chlorogenic acid, cynaroside, 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju were measured by HPLC. The effective period of the preparation was calculated according to Arrhinius index law. Quantitative determination of 3,5-O-discaffeoylquinc acid, cynaroside, chlorogenic acid in Hangju and Gongju were analyzed by HPLC.</p><p><b>RESULT</b>The stable life of Hangbaiju has been determined as 2.25 years. The stable life of Gongju has been determined as 4.31 years.</p><p><b>CONCLUSION</b>The high temperature is not conducive to the stability of Hangbaiju and Gongju, which needs to be placed in a dark and cool place.</p>