Levels of regulatory T cells in peripheral blood of children with idiopathic thrombocytopenic purpura / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 282-284, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-308811
ABSTRACT
<p><b>OBJECTIVE</b>To study the levels of CD4+CD25+CD127- and CD3+CD4-CD8- regulatory T (Treg) cells in peripheral blood of children with idiopathic thrombocytopenic purpura (ITP).</p><p><b>METHODS</b>The flow cytometry was used to detect the expression of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells in peripheral blood of 33 children with ITP and 21 healthy children.</p><p><b>RESULTS</b>The expression levels of CD4+CD25+CD127-[(2.7±1.7)% vs (4.8±1.6)%; P<0.01]and CD3+CD4-CD8-[(5.2±3.1)% vs (8.1±3.5)%; P<0.01]Treg cells in children with ITP were significantly lower than in the controls.</p><p><b>CONCLUSIONS</b>The expression levels of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells decrease in children with ITP, suggesting that CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells might play a role in the pathogenesis of ITP.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antígenos CD4
/
Púrpura Trombocitopênica Idiopática
/
Complexo CD3
/
Linfócitos T Reguladores
/
Alergia e Imunologia
/
Subunidade alfa de Receptor de Interleucina-2
/
Subunidade alfa de Receptor de Interleucina-7
/
Citometria de Fluxo
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2011
Tipo de documento:
Artigo
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