Preimplantation genetic diagnosis for Down syndrome pregnancy / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 515-521, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-308974
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of preimplantation genetic diagnosis (PGD) conducted for women who had Down syndrome pregnancy previously.</p><p><b>METHODS</b>Trisomy 21 was diagnosed by using fluorescence in site hybridization (FISH) before embryo transfer in two women who had Down syndrome pregnancies. Each received one or two PGD cycles respectively.</p><p><b>RESULTS</b>Case 1 one PGD cycle was conducted, two oocytes were fertilized and biopsied. One embryo is of trisomy 21 and the other of monosomy 21. No embryo was transferred. Case 2 two PGD cycles were conducted, in total, sixteen oocytes were fertilized and biopsied. Four embryos were tested to be normal, six of trisomy 21, and one of monosomy 21. Five had no signal. Four normal embryos were transferred but no pregnancy resulted.</p><p><b>CONCLUSION</b>For couples who had pregnancies with Down syndrome previously, PGD can be considered, and has been shown to be an effective strategy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cromossomos Humanos Par 21
/
Hibridização in Situ Fluorescente
/
Síndrome de Down
/
Diagnóstico Pré-Implantação
/
Diagnóstico
/
Genética
/
Monossomia
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
/
Gravidez
Idioma:
Inglês
Revista:
Journal of Zhejiang University. Science. B
Ano de publicação:
2007
Tipo de documento:
Artigo
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