Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 221-227, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-309014
ABSTRACT
Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease of unknown etiology. The exact pathogenesis of pulmonary arterial hypertension is still not well known. In the past decades, many protein molecules have been found to be involved in the development of IPAH. With proteomic techniques, profiling of human plasma proteome becomes more feasible in searching for disease-related markers. In present study, we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum. Thirteen spots had changed significantly in IPAH compared with healthy controls and were identified by LC-MS/MS. Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Proteínas Sanguíneas
/
Eletroforese em Gel Bidimensional
/
Bases de Dados de Proteínas
/
Proteômica
/
Genética
/
Hipertensão Pulmonar
/
Cromatografia Gasosa-Espectrometria de Massas
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Zhejiang University. Science. B
Ano de publicação:
2007
Tipo de documento:
Artigo
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