BMAL1 gene regulates the osteogenic differentiation of bone marrow mesenchymal stem cells / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 312-316, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-309131
ABSTRACT
Periodontitis is a chronic infective disease characterized as the destruction of the supporting tissues of the teeth. Bone marrow mesenchymal stem cells, which are ideal adult stem cells for the regeneration of supporting tissues, may play important roles in restoring the structure and function of the periodontium and in promoting the treatment of periodontal disease. As a consequence, the characteristics, especially osteogenic differentiation mechanism, of these stem cells have been extensively investigated. The regulation of the physiological behavior of these stem cells is associated with BMAL1 gene. This gene is a potential treatment target for periodontal disease, although the specific mechanism remains inconclusive. This study aimed to describe the characteristics of BMAL1 gene and its ability to regulate the osteogenic differentiation of stem cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Ligamento Periodontal
/
Periodontite
/
Fisiologia
/
Regeneração
/
Dente
/
Periodonto
/
Células da Medula Óssea
/
Células-Tronco Hematopoéticas
/
Diferenciação Celular
Limite:
Adulto
/
Humanos
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2016
Tipo de documento:
Artigo
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