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Anti-BP180 NC16A IgG Titres as an Indicator of Disease Activity and Outcome in Asian Patients with Bullous Pemphigoid
Annals of the Academy of Medicine, Singapore ; : 119-126, 2015.
Artigo em Inglês | WPRIM | ID: wpr-309533
ABSTRACT
<p><b>INTRODUCTION</b>Anti-BP180 IgG titres were observed to parallel disease activity in case series of bullous pemphigoid (BP). This study aimed to examine whether anti-BP180 titres are an indicator of disease severity, clinical course and outcome in Asian patients with BP.</p><p><b>MATERIALS AND METHODS</b>This was a prospective observational study conducted between March 2005 and March 2008 in the Immunodermatology Clinic at the National Skin Centre, Singapore. Disease activity and anti-BP180 IgG titres were measured 4-weekly for 12 weeks and during disease flares and clinical remission. Associations between anti-BP180 titres and disease activity, disease flare, clinical remission and cumulative prednisolone dose were examined.</p><p><b>RESULTS</b>Thirty-four patients with newly diagnosed BP were recruited. Median follow-up duration was 3 years. Notable correlations between disease activity and anti-BP180 titres were at baseline (r = 0.51, P = 0.002), and disease flare (r = 0.85, P <0.001). Lower titres at Week 12 were associated with greater likelihood of clinical remission (P = 0.036). Post hoc, patients with anti-BP180 titres above 87.5 U/mL at time of diagnosis who reached remission within 2 years of diagnosis received significantly higher cumulative doses (mg/kg) of prednisolone (median, 72.8; range, 56.5 to 127.1) than those with titres <87.5 U/mL (median, 44.6; range, 32.5 to 80.8); P = 0.025).</p><p><b>CONCLUSION</b>Anti-BP180 titres may be a useful indicator of disease activity at time of diagnosis and at disease flare. Lower titres at Week 12 may predict greater likelihood of clinical remission. Titres above 87.5 U/mL at time of diagnosis may suggest the need for higher cumulative doses of prednisolone to achieve remission within 2 years.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Singapura / Autoanticorpos / Autoantígenos / Sangue / Ensaio de Imunoadsorção Enzimática / Anticorpos Anti-Idiotípicos / Valor Preditivo dos Testes / Estudos Prospectivos / Penfigoide Bolhoso / Avaliação de Resultados em Cuidados de Saúde Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Annals of the Academy of Medicine, Singapore Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Singapura / Autoanticorpos / Autoantígenos / Sangue / Ensaio de Imunoadsorção Enzimática / Anticorpos Anti-Idiotípicos / Valor Preditivo dos Testes / Estudos Prospectivos / Penfigoide Bolhoso / Avaliação de Resultados em Cuidados de Saúde Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Annals of the Academy of Medicine, Singapore Ano de publicação: 2015 Tipo de documento: Artigo