Lung adenoma development and NK activity in mice treated with multiple carcinogens
Journal of Korean Medical Science
;
: 1-5, 1992.
Artigo
em Inglês
| WPRIM
| ID: wpr-30961
ABSTRACT
A wide-spectrum initiation model was investigated in mice. Sequential treatments with diethylnitrosamine, urethane and N-methylnitrosourea, with or without a promoter, phenobarbital, resulted in tumor formation in the lungs in 85-90% of animals, but did not produce any tumorous lesions in other organs. The lung tumors were adenomas and the mean number of adenomas was 2.2-2.6 per mouse. Phenobarbital combination had no additive effect on lung tumor incidence and multiplicity. Splenic NK cell activity showed inconsistent increment in the carcinogen plus phenobarbital-treated group during the experiment (P less than 0.05).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenobarbital
/
Uretana
/
Células Matadoras Naturais
/
Distribuição Aleatória
/
Adenoma
/
Dietilnitrosamina
/
Neoplasias Pulmonares
/
Metilnitrosoureia
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
1992
Tipo de documento:
Artigo
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