DAZL and male infertility: an update / 中华男科学杂志
National Journal of Andrology
;
(12): 647-650, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-309660
ABSTRACT
DAZL, a member of the DAZ family, plays a key role in human spermatogenesis. It regulates the promoter via genetic modification, especially DNA methylation, promoting the transcription of DAZL. Besides, the relation of DAZL SNPs with male infertility has been a hot spot of research for many years. It is deduced that local and ethnic factors may be associated with the failure of spermatogenesis. This article presents an overview on the results of recent studies, changes in the DNA methylation of DAZL in spermatogenesis, and the association of DAZL SNPs with male infertility, aiming to provide a new theoretical basis and clinical strategy for the treatment of male infertility.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espermatogênese
/
Proteínas de Ligação a RNA
/
Metilação de DNA
/
Polimorfismo de Nucleotídeo Único
/
Genética
/
Infertilidade Masculina
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2014
Tipo de documento:
Artigo
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