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Experimental observation on the effects of different chitosan on preventing peritoneal adhesion in rats / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 1177-1181, 2005.
Artigo em Chinês | WPRIM | ID: wpr-309928
ABSTRACT
This experiment was designed to investigate the effects of different chitosan on preventing peritoneal adhesion in rats. 240 SD rats were divided into 2 jumbogroups jumbogroup A (144 rats) treated with chitosan gel and jumbogroup B (96 rats) with chitosan/gelatin mixed film. In jumbogroup A, 144 rats were randomly divided into 3 groups further, and different methods were used to induce peritoneal adhesions in each group while in the experiment group the wounded processus vermiformis was coated with chitosan gel before it was put back into the abdominal cavity. In jumpbogroup B, 96 rats were randomly divided into 4 groups (24 each) after surgical induction of perioneal adhesions; group B1 served as control group while in groups B2, B3 and B4, pure chitosan film and the chitosan film containing gelatin were respectively spread over the surface of the wounded. 2 and 4 weeks after surgical induction, exploratory laparatomy was performed on the rats to evaluate peritoneal adhesion, and the adhesive tissues were examined histopathologically. The results show that chitosan gel has perfect protective efficacy against traumatic or ischemic peritoneal adhesion, but pure chitosan film and the film chitosan containing gelatin could exacerbate peritoneal adhesion further.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doenças Peritoneais / Farmacologia / Distribuição Aleatória / Química / Aderências Teciduais / Ratos Sprague-Dawley / Quitosana / Gelatina / Géis Limite: Animais Idioma: Chinês Revista: Journal of Biomedical Engineering Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doenças Peritoneais / Farmacologia / Distribuição Aleatória / Química / Aderências Teciduais / Ratos Sprague-Dawley / Quitosana / Gelatina / Géis Limite: Animais Idioma: Chinês Revista: Journal of Biomedical Engineering Ano de publicação: 2005 Tipo de documento: Artigo