Five years trial of entecavir for chronic hepatitis B patients failed with lamivudine therapy in the Chongqing area / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 338-341, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-310091
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of five-year trail of entecavir for chronic hepatitis B patients failed with lamivudine therapy in the Chongqing area.</p><p><b>METHODS</b>32 patients failed with lamivudine therapy were enrolled in this study. In the double-blind phase, patients were randomly divided into entecavir 1.0 mg/d group (n = 28) and placebo group(n = 4) for 12 weeks. In the open-lable phase, patients received ETV 1.0 mg/d for 240 weeks. HBV DNA level, liver function, HBV serology were observed.</p><p><b>RESULTS</b>The mean reduction in HBV DNA level at week 12 was 4.05 log10 copies/ml in ETV group, and 0.08 log10 copies/ml in placebo group (P less than 0.05). The mean of HBV DNA level after 240 weeks of ETV treatment was decreased to 2.58 log10 copies/ml. The proportion of patients with HBV DNA less than 3 log10 copies/ml was 0, 6.25%, 15.6% , 50%, and 57.14% at 0, 8, 24, 96 and 240 weeks respectivfely. There were 2 patients with HBsAg seroconversion and 4 patients with HBeAg seroconversion at the end of the study. The ALT level returned to normal at week 12 and remained normal throughout the following 240 weeks. One patient had a severe adverse event during the trail.</p><p><b>CONCLUSION</b>Entecavir is effective and safe for the chronic hepatitis B patients failed with lamivudine therapy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Fatores de Tempo
/
Virologia
/
Replicação Viral
/
Sangue
/
DNA Viral
/
Método Duplo-Cego
/
Resultado do Tratamento
/
Lamivudina
/
Hepatite B Crônica
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2009
Tipo de documento:
Artigo
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