T lymphocyte subgroups and serum levels of trace elements in patients with diarrhea type of irritable bowel syndrome / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 634-637, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-310402
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the T lymphocyte subgroups and the levels of serum zinc (Zn), selenium (Se), iron (Fe), copper (Cu) in patients with diarrhea type of irritable bowel syndrome (D-IBS).</p><p><b>METHODS</b>A total of 30 D-IBS patients and 30 control subjects were enrolled in this study, and their peripheral blood samples were collected. The percentage of peripheral CD3, CD4, CD8 T lymphocytes were analyzed by flow cytometry, and the ratio of CD4/CD8 was calculated. Serum Zn, Fe and Cu levels were determined by atomic absorption spectrometry(AAS), and the Se level by atomic fluorometry.</p><p><b>RESULT</b>Compared with control group,the percentage of CD4 T lymphocyte and the ratio of CD4/CD8 in D-IBS group were significantly lower (P<0.01). However, there was no significant difference in serum Zn, Se, Fe, Cu levels between two groups (P>0.05).</p><p><b>CONCLUSION</b>The declines of peripheral blood CD4 T lymphocytes and the ratio of CD4/CD8 may suggest a cellular immune abnormality in D-IBS patients. There was no significant difference in trace elements levels between the two groups.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Selênio
/
Oligoelementos
/
Zinco
/
Sangue
/
Estudos de Casos e Controles
/
Subpopulações de Linfócitos T
/
Relação CD4-CD8
/
Cobre
/
Síndrome do Intestino Irritável
/
Diarreia
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2008
Tipo de documento:
Artigo
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