Arrhythmia triggered by stretching rabbit left ventricles and the block effect of streptomysin / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 286-289, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-310744
ABSTRACT
<p><b>AIM</b>To observe the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, and to investigate its possible mechanisms.</p><p><b>METHODS</b>Stretch (120 mmHg, 50 ms) was applied in the end of action potential by the pressure-clamp technique to observe if there would be any changes in rabbit cardiac activity and streptomycin (500 micromol/L) was used to identify the mechanism.</p><p><b>RESULTS</b>Stretch in the end of action potential caused arrhythmia (P < 0.05) and streptomycin blocked the above effect (P < 0.05).</p><p><b>CONCLUSION</b>Streptomycin could block the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, which indicates that stretch-activated ion channels involve it.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fisiologia
/
Arritmias Cardíacas
/
Propriocepção
/
Técnicas In Vitro
/
Potenciais de Ação
/
Estreptomicina
/
Ventrículos do Coração
/
Canais Iônicos
/
Mecanorreceptores
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2008
Tipo de documento:
Artigo
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