Effects of simulated hypoxia on dielectric properties of mouse erythrocytes / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To explore the influence of simulated altitude hypoxia on dielectric properties of mouse erythrocytes.</p><p><b>METHODS</b>Experimental animals were divided into the plain control group(control) and simulated altitude hypoxia group (altitude). The AC impedance of mouse erythrocytes was measured with the Agilent 4294A impedance analyzer, the influence of simulated altitude hypoxia on dielectric properties of mouse erythrocytes was observed by cell dielectric spectroscopy, Cole-Cole plots, loss factor spectrum, loss tangent spectrum, and curve fitting analysis of Cole-Cole equation.</p><p><b>RESULTS</b>After mice were exposed to hypoxia at simulated 5000 m altitude for 4 weeks, permittivity at low frequency (epsilonl) and dielectric increment (deltaepsilon) increased 57% and 59% than that of control group respectively, conductivity at low frequency (kappal) and conductivity at high frequency (kappah) reduced 49% and 11% than that of control group respectively.</p><p><b>CONCLUSION</b>The simulated altitude hypoxia could arise to increase dielectric capability and depress conductive performance on mouse erythrocytes.</p>