Study on steroidal saponins from Dioscorea zingiberensis and their platelet aggregation activities / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3782-3787, 2014.
Article
em Zh
| WPRIM
| ID: wpr-310989
Biblioteca responsável:
WPRO
ABSTRACT
Using the absorbent resin, silica gel and ODS column chromatography as well as semi-preparative HPLC, ten compounds were isolated from 70% ethanol extract of tubers of Dioscorea zingiberensis C. H. Wright, and their structures were elucidated as trigoneoside XIIIa (1), parvifloside (2), trigoneoside IVa (3), deltoside (4), protobioside (5), lilioglycoside k (6), zingiberensis newsaponin I (7), deltonin (8), prosapogenin A of dioscin (9), and trillin (10) on the basis of NMR and MS spectral data analysis. Among these compounds, 1, 3, 5 and 6 were isolated from this plant for the first time. In the screening test on platelet aggregation, compounds 7 and 8 exhibited induction effect on platelet aggregation, while compound 9 exhibited significant inhibitory effect on platelet aggregation in vitro.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Saponinas
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Espectrometria de Massas
/
Medicamentos de Ervas Chinesas
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Estrutura Molecular
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Química
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Agregação Plaquetária
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Ratos Wistar
/
Dioscorea
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2014
Tipo de documento:
Article