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Regulative mechanisms of oxidative stress in kidney in diabetic nephropathy and interventional effects of Chinese herbal medicine / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 3707-3712, 2014.
Artigo em Chinês | WPRIM | ID: wpr-311004
ABSTRACT
In the development of diabetic nephropathy (DN), reactive oxygen specie (ROS) over much in vivo leads to oxidative stress(OS)-related renal injuries, which are characterized by the structural and functional changes in glomerular and renal tubular cells in morphology. The regulative approaches of OS involve the several signaling pathways, in which, both p38 mitogen-activated protein kinase (MAPK) signaling pathway and adenosine monophosphate-activated protein kinase (AMPK) signaling pathway play the important roles as the target of anti-oxidants. The interventional actions of Chinese herbal compound prescriptions and the extracts of single Chinese herbal medicine (CHM) on OS in the kidney in DN include regulating the balance between ROS and antioxidants, reducing the production of AGEs, inhibiting the expression of growth factors and intervening the activity of signaling pathways.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Medicamentos de Ervas Chinesas / Transdução de Sinais / Resultado do Tratamento / Estresse Oxidativo / Nefropatias Diabéticas / Tratamento Farmacológico / Rim / Metabolismo Limite: Animais / Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Medicamentos de Ervas Chinesas / Transdução de Sinais / Resultado do Tratamento / Estresse Oxidativo / Nefropatias Diabéticas / Tratamento Farmacológico / Rim / Metabolismo Limite: Animais / Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2014 Tipo de documento: Artigo